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KMID : 0359920100290050600
Korean Journal of Nephrology
2010 Volume.29 No. 5 p.600 ~ p.605
2 Cases of Severe Hyperchloremic Metabolic Acidosis after Orthotopic Neobladder Replacement and Augmentation Enterocystoplasty
Lee Han-Kyu

Sun Hui-Kyuoung
Kim Dong-Ki
Oh Kook-Hwan
Kim Yon-Su
Ahn Curie
Han Jin-Suk
Kim Suhng-Gwon
Kwak Cheol
Oh Seung-June
Joo Kwon-Wook
Abstract
The use of intestinal segments in the reconstruction and plasty of urinary bladder for malignant or nonmalignant conditions is widely accepted. Metabolic derangements including hyperchloremic metabolic acidosis and malabsorption of lipid may occur after surgery. Main pathophysiology of hyperchloremic metabolic acidosis is the exchange of urinary chloride with luminal bicarbonate and duration of urine in contact with the intestinal mucosa can affect the severity of metabolic acidosis. We experienced two cases of severe hyperchloremic metabolic acidosis which developed in patients with chronic kidney disease, urinary tract infection and orthotopic neobladder or augmentation enterocystoplasty for the treatment of bladder cancer and neurogenic bladder, respectively.
KEYWORD
Urinary diversion, Acidosis, Urinary bladder
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