KMID : 0359920100290050600
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Korean Journal of Nephrology 2010 Volume.29 No. 5 p.600 ~ p.605
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2 Cases of Severe Hyperchloremic Metabolic Acidosis after Orthotopic Neobladder Replacement and Augmentation Enterocystoplasty
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Lee Han-Kyu
Sun Hui-Kyuoung Kim Dong-Ki Oh Kook-Hwan Kim Yon-Su Ahn Curie Han Jin-Suk Kim Suhng-Gwon Kwak Cheol Oh Seung-June Joo Kwon-Wook
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Abstract
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The use of intestinal segments in the reconstruction and plasty of urinary bladder for malignant or nonmalignant conditions is widely accepted. Metabolic derangements including hyperchloremic metabolic acidosis and malabsorption of lipid may occur after surgery. Main pathophysiology of hyperchloremic metabolic acidosis is the exchange of urinary chloride with luminal bicarbonate and duration of urine in contact with the intestinal mucosa can affect the severity of metabolic acidosis. We experienced two cases of severe hyperchloremic metabolic acidosis which developed in patients with chronic kidney disease, urinary tract infection and orthotopic neobladder or augmentation enterocystoplasty for the treatment of bladder cancer and neurogenic bladder, respectively.
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KEYWORD
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Urinary diversion, Acidosis, Urinary bladder
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